This study highlights a possible significance of cytosine methylation in the physiology of H. hpyAVIBM from strain 26695 is able to complement mutant SS1 and AM5 strains. AM5Δ hpyAVIBM mutant strain has a different LPS profile and is able to induce high IL-8 production compared to wild-type. pylori strains AM5and SS1 has a significant effect on the expression of number of genes belonging to motility, adhesion and virulence. In this study, it was observed by microarray analysis and RT-PCR, that deletion of an orphan C 5 -cytosine methyltransferase, hpyAVIBM in H. The role of N 6 - adenine methylation in bacterial gene regulation and virulence is well established but not much is known about the effect of C 5 -cytosine methylation on gene expression in prokaryotes. Restriction-modification genes are a major part of strain-specific genes present in H. pylori uses diverse mechanisms to modulate its interaction with the host in order to promote chronic infection and overcome host immune response. Helicobacter pylori is an important human pathogen and one of the most successful chronic colonizers of the human body.
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